Relationship betweenHelicobacter pyloriand DNA mismatch repair system
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چکیده
منابع مشابه
DNA mismatch repair.
DNA mismatch repair (MMR) is an evolutionarily conserved process that corrects mismatches generated during DNA replication and escape proofreading. MMR proteins also participate in many other DNA transactions, such that inactivation of MMR can have wide-ranging biological consequences, which can be either beneficial or detrimental. We begin this review by briefly considering the multiple functi...
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Some cases of endometrial cancer are associated with a familial tumor and are referred to as hereditary nonpolyposis colorectal cancer (HNPCC or Lynch syndrome). Lynch syndrome is thought to be induced by germline mutation of the DNA mismatch repair (MMR) gene. An aberration in the MMR gene prevents accurate repair of base mismatches produced during DNA replication. This phenomenon can lead to ...
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The mechanisms that concern DNA repair have been studied in the last years due to their consequences in cellular homeostasis. The diverse and damaging stimuli that affect DNA integrity, such as changes in the genetic sequence and modifications in gene expression, can disrupt the steady state of the cell and have serious repercussions to pathways that regulate apoptosis, senescence, and cancer. ...
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Safeguarding the integrity of the genome should not be left to chance. Indeed, all organisms have highly effective mechanisms to detect and remove errors and lesions in DNA. DNA mismatch repair (MMR) serves as the final safeguard in assuring the fidelity of DNA replication from bacteria to humans and backstops the nucleotide selection and exonuclease proofreading activities of replicative polym...
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ژورنال
عنوان ژورنال: World Chinese Journal of Digestology
سال: 2007
ISSN: 2219-2859
DOI: 10.11569/wcjd.v15.i1.51